Synthesis and Biological Evaluation of New Mannose Derived Immunomodulating Adamantyltripeptides

Ribić, Rosana and Habjanec, Lidija and Vranešić, Branka and Frkanec, Ruža and Tomić, Srđanka (2011) Synthesis and Biological Evaluation of New Mannose Derived Immunomodulating Adamantyltripeptides. Croatica Chemica Acta, 84 (2). pp. 233-244. ISSN 0011-1643

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Abstract

A novel class of mannosylated adamantyltripeptides, general formula of which is α-Man-OCH2CH(CH3)CO-AdGly-L-Ala-D-isoGln, were prepared, characterized, and their possible immunomodulatory properties investigated in some preliminary tests in vivo. All newly synthesized glycopeptides comprise in their structure the adamantylglycyl moiety linked to the dipeptide L-Ala-D-isoGln, as well as mannose. Adjuvant activity of mannosylated adamant-2-yl tripeptides was tested in the mouse model using ovalbumin as an antigen and in comparison to the peptidoglycan monomer (PGM, β-D-GlcNAc- (1→4)-D-MurNAc-L-Ala-D-isoGln-mesoDAP(εNH2)-D-Ala-D-Ala).

Item Type: Article
Keywords: O-mannopyranosides, adamantyltripeptides, peptidoglycan monomer, immunomodulation
Date: 2011
Subjects: NATURAL SCIENCES > Chemistry
Divisions: Faculty of Science > Department of Chemistry
Publisher: Hrvatsko kemijsko društvo
Related URLs:
Depositing User: Branka Maravic
Date Deposited: 09 May 2014 09:43
Last Modified: 09 May 2014 09:43
URI: http://digre.pmf.unizg.hr/id/eprint/1082

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