Synthesis and Biological Activity of Mannose Conjugates with 1-Adamantamine and Ferrocene Amines

Ribić, Rosana and Kovačević, Monika and Petrović-Peroković, Vesna and Gruić-Sovulj, Ita and Rapić, Vladimir and Tomić, Srđanka (2010) Synthesis and Biological Activity of Mannose Conjugates with 1-Adamantamine and Ferrocene Amines. Croatica Chemica Acta, 83 (4). pp. 421-431. ISSN 0011-1643

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Abstract

Pure α- and β-anomers of O-mannosyl conjugates with 1-adamantamine and ferrocene amines were prepared. The sugar moiety in these glycoconjugates is connected to the amine by a chiral linker (methyl (R)-3-hydroxy-2-methyl propanoate and/or methyl (S)-3-hydroxy-2-methyl propanoate). The α-D-mannopyranosides with adamantane and ferrocene aglycon parts were tested using the hemagglutination assay (inhibition of the agglutination of guinea pig erythrocytes by type 1 fimbriated E. coli HB101 (pPKl4)). All glycoconjugates showed inhibitory potencies in the mM range.

Item Type: Article
Keywords: O-Mannopyranosides, 1-Adamantamine, Ferrocene Amines, Hemagglutination
Date: 2010
Subjects: NATURAL SCIENCES > Chemistry
Divisions: Faculty of Science > Department of Chemistry
Publisher: Hrvatsko kemijsko društvo
Related URLs:
Depositing User: mag. bibl. Ana Šafran
Date Deposited: 09 May 2014 10:47
Last Modified: 09 May 2014 10:47
URI: http://digre.pmf.unizg.hr/id/eprint/1094

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