Seryl-tRNA Synthetases: Enzymes with Multiple Personalities

Bilokapić, Silvija and Ban, Nenad and Weygand-Đurašević, Ivana (2009) Seryl-tRNA Synthetases: Enzymes with Multiple Personalities. Croatica Chemica Acta, 82 (2). pp. 493-501. ISSN 0011-1643

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Abstract

Seryl-tRNA synthetases (SerRS) are essential enzymes responsible for aminoacylation of cognate transfer-RNAs (tRNAsSer) with serine, which is then incorporated into the proteins being synthesized on the ribosome. Although tRNA synthetases are usually a very conserved class of enzymes, phylogenic analyses revealed the existence of two distinct types of serine-charging enzymes; a standard or bacterial-type SerRS is found in the majority of organisms (prokaryotes, eukaryotes and archaea), while a highly diverged methanogenic-type SerRS is confined to the methanogenic archaea. We give a short overview on our recent biochemical and structural contributions to the understanding of different molecular mecha-nisms of tRNA serylation.

Item Type: Article
Keywords: seryl-tRNA synthetase; transfer RNA; synthetase crystal structure; synthetase: tRNA model
Date: 2009
Subjects: NATURAL SCIENCES > Biology > Biochemistry and Molecular Biology
Divisions: Faculty of Science > Department of Chemistry
Publisher: Hrvatsko kemijsko društvo
Related URLs:
Depositing User: Branka Maravic
Date Deposited: 09 May 2014 13:25
Last Modified: 09 May 2014 13:25
URI: http://digre.pmf.unizg.hr/id/eprint/1117

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