Spectrophotometric Studies of Some Novel Derivatives of Pyridinium Chloride

Lovrić, Jasna and Burger, Nicoletta and Deljac, Vjera and Mihalić, Zlatko (1999) Spectrophotometric Studies of Some Novel Derivatives of Pyridinium Chloride. Croatica Chemica Acta, 72 (1). pp. 123-133. ISSN 0011-1643

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Abstract

The UV-Vis and IR characteristics of five novel aralkyl derivatives of pyridinium chloride, found to be reversible inhibitors of acetylcholinesterase, are reported. The dissociation constants of the individual keto and oxime functional groups were determined spectrophotometrically and discussed in terms of the known pK values of compounds with similar structures. The three examined derivatives of the phenacylpyridinium type contain in solution a considerable proportion of the enol form while their next higher homologues are present predominately in their keto forms. AM1 molecular-orbital calculations show that the much higher acidity of α-CH2 group of benzoylethylpyridinium type compounds is a consequence of an anomeric effect.

Item Type: Article
Date: 1999
Subjects: NATURAL SCIENCES > Chemistry
Divisions: Faculty of Science > Department of Chemistry
Publisher: Hrvatsko kemijsko društvo
Related URLs:
Depositing User: mag. bibl. Ana Šafran
Date Deposited: 26 May 2014 10:34
Last Modified: 27 May 2014 12:05
URI: http://digre.pmf.unizg.hr/id/eprint/1725

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