IL-18 gene promoter polymorphisms in patients with type i diabetes in Croatia

Jemin, Nikolina (2012) IL-18 gene promoter polymorphisms in patients with type i diabetes in Croatia. Diploma thesis, Faculty of Science > Department of Biology.

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Abstract

Type 1 diabetes mellitus (T1DM) is a result of an autoimmune destruction of pancreatic beta cells. IL-18 has an important role in autoimmunity and there is an association of IL-18 polymorphisms with the development of T1DM in some, but not all populations. The aim of our study was to evaluate the Croatian population by determing the frequency of IL-18-137 G/C and 607 C/A polymorphisms in T1DM patients (N=187) compared to healthy subjects (N=236) by PCR method. The allelic genotype and haplotype frequencies of both polymorphisms did not differ significantly between patient and control group. There was no correlation of genotype with the age at T1DM onset and glycolysed hemoglobin. However, patients with the -607 (AA) genotype require lower daily insulin dosage compared to patients with the -607 (CA i CC) genotype (p=0.031). Results indicate that analyzed polymorphisms may influence insulin dosage, glycemic control and therapy optimisation in Croatian T1DM patients.

Item Type: Thesis (Diploma thesis)
Keywords: type I diabetes, autoimmunity, interleukine-18, polymorphism, IL-18-137(G/C), IL-18-607(C/A)
Supervisor: Popović Hadžija, Marijana
Co-supervisor: Galov, Ana
Date: 2012
Number of Pages: 51
Subjects: NATURAL SCIENCES > Biology
Divisions: Faculty of Science > Department of Biology
Depositing User: Grozdana Sirotic
Date Deposited: 29 May 2014 11:27
Last Modified: 29 May 2014 11:27
URI: http://digre.pmf.unizg.hr/id/eprint/1924

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