Collective Behavior of Antagonistically Acting Kinesin-1 Motors

Leduc, Cecile and Pavin, Nenad and Julicher, Frank and Diez, Stefan (2010) Collective Behavior of Antagonistically Acting Kinesin-1 Motors. Physical Review Letters, 105 (12). pp. 128103-4. ISSN 0031-9007

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In many subcellular force-generating systems, groups of motor proteins act antagonistically. Here, we present an experimental study of the tug of war between superprocessive kinesin-1 motors acting on antiparallel microtubule doublets in vitro. We found distinct modes of slow and fast movements, as well as sharp transitions between these modes and regions of coexistence. We compare our experimental results to a quantitative theory based on the physical properties of individual motors. Our results show that mechanical interactions between motors can collectively generate coexisting transport regimes with distinct velocities.

Item Type: Article
Date: September 2010
Subjects: NATURAL SCIENCES > Physics > Biophysics and Medical Physics
Additional Information: Copyright (2010) by the American Physical Society.
Divisions: Faculty of Science > Department of Physics
Project code: 119-0982464-1253
Publisher: American Physical Society
Depositing User: Gordana Stubičan Ladešić
Date Deposited: 31 May 2014 20:31
Last Modified: 12 Feb 2016 16:06

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