Relevance of complement activation in the liver graft

Buhin, Maida (2014) Relevance of complement activation in the liver graft. Doctoral thesis, Faculty of Science > Department of Biology.

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Aim of the study is to determine complement activation in transplanted liver. We studied 113 orthotopic liver transplantations in 107 patients, from January 2008 until December 2009. We ana-lyzed graft rejection using existing data and further testing of stored serum and tissue samples, tested for presence of HLA-antibodies by Luminex or CDC tests and determined the C4d com-plement component (marker of complement activation). Our results confirmed frequent comple-ment activation in the graft, present in different injuries, suggesting various complement activation paths. Centrilobular localization of C4d is more common in «zero» biopsies, while portal localiza-tion is more frequent in biopsies with confirmed rejection. We showed a positive correlation be-tween rejection and C4d expression. We identified a small group of subjects with positive serum HLA-antibodies and more frequent episodes of rejections as well as a more complicated postoper-ative recovery, suggesting a significant role of antibodies and compliment activation in graft inju-ry.

Item Type: Thesis (Doctoral thesis)
Keywords: orthotopic liver transplantation, HLA antibodies, CDC (Complement Dependent Cy-totoxicity) test, Luminex test, C4d, acute rejection
Supervisor: Knotek, Mladen
Date: 2014
Number of Pages: 115
Subjects: NATURAL SCIENCES > Biology
Divisions: Faculty of Science > Department of Biology
Depositing User: Grozdana Sirotic
Date Deposited: 03 Jun 2014 08:26
Last Modified: 24 Sep 2014 08:20

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