Effect of perinatal treatment with serotonin agonists on immunological and hematological parameters in adult rats

Lipovec, Valentina (2012) Effect of perinatal treatment with serotonin agonists on immunological and hematological parameters in adult rats. Diploma thesis, Faculty of Science > Department of Biology.

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Abstract

Serotonin (5HT) is a biogenic amine present in the central nervous system and peripheral tissues, including components of the immune system. During embryonic and fetal development 5HT regulates neurogenesis, while later it acts as a signaling molecule mediating various physiological functions. In this thesis, the influence of the disturbed 5HT homeostasis induced by perinatal treatment with agonists 5-hydroxytryptophan (5HTP) or tranylcypromine (TCP), on the immunological and hematological parameters (number of cells in the lymph nodes, spleen and blood, differential blood count and serum cytokine levels) has been studied in healthy adult rats. Perinatal exposure to the increased 5HT levels has significantly decreased number of platelets in both experimental groups, significantly increased total number of leukocytes, as well as numbers of lymphocytes and neutrophils, in TCP-treated rats, and indicatively influenced levels of cytokines Il-1a and RANTES in serum of the treated animals. The results indicate possible role of serotonin in hematopoiesis and immune response, which will be further explored after inducing the immune response.

Item Type: Thesis (Diploma thesis)
Keywords: 5-hydroxytryptophan, tranylcipromine, homeostasis, cytokines, blood cells
Supervisor: Hranilović, Dubravka
Co-supervisor: Erhardt, Julija
Date: 2012
Number of Pages: 53
Subjects: NATURAL SCIENCES > Biology
Divisions: Faculty of Science > Department of Biology
Depositing User: Grozdana Sirotic
Date Deposited: 03 Jun 2014 12:45
Last Modified: 03 Jun 2014 12:45
URI: http://digre.pmf.unizg.hr/id/eprint/2174

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