Immunohistochemical significance of cyclin D1 and p27 in evaluation of metastatic potential of thyroid papillary microcarcinoma

Biškup, Natalija (2012) Immunohistochemical significance of cyclin D1 and p27 in evaluation of metastatic potential of thyroid papillary microcarcinoma. Diploma thesis, Faculty of Science > Department of Biology.

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Abstract

Thyroid papillary microcarcinoma is a papillary carcinoma less than or equal to one centimeter in diameter. Papillary mikrocarcinoma has an excelent prognosis if has no metastasis in regional lymph nodes. Alteration in control of the cell division is a basis of carcinogenesis. Cell cycle is controlled by cyclin-dependent kinases activated through complexes with cyclins. Studies on papillary carcinomas showed that underexpression of p27 and overexpression of cyclin D1 correlate with metastases. We determined expression of cyclin D1 and p27 using immunohistochemical assay. Appearance of intraglandular dissemination in another lobe of the thyroid is a significant factor of tumor aggressive behavior and appearance of metastases in regional lymph nodes (p<0.001). Size of a tumor negatively correlate with nuclear expression of p27 (P=0.036). Nuclear expression of cyclin D1 shows statistically significant negative correlation with nuclear and cytoplasmic expression of p27 (P=0.023 and P=0.001, retrospectively). Expression of cyclin D1 and p27 did not significantly correlate with appearance of metastases in thyroid papillary microcarcinoma.

Item Type: Thesis (Diploma thesis)
Keywords: cyclin-D1, p27, thyroid cancer, prognostic factor, immunohistochemistry
Supervisor: Knežević, Fabijan
Co-supervisor: Benković, Vesna
Date: 2012
Subjects: NATURAL SCIENCES > Biology
Divisions: Faculty of Science > Department of Biology
Depositing User: Grozdana Sirotic
Date Deposited: 06 Jun 2014 07:29
Last Modified: 18 Sep 2014 12:43
URI: http://digre.pmf.unizg.hr/id/eprint/2273

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