Effectivity of ethanolic extract of propolis animal model of psoriasis

Davda, Bojana (2011) Effectivity of ethanolic extract of propolis animal model of psoriasis. Diploma thesis, Faculty of Science > Department of Biology.

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Psoriasis is a hyperproliferative chronic inflammatory skin disease manifested in multiple erythematosquamous plaques, most commonly localized in the area of extremities and the scalp. An animal model was used to examine the anti-inflammatory efficiency of propolis, a natural antioxidant, and its application in treatment of psoriasis. For research purposes, mice were bread at the Department of Animal Physiology, Faculty of Science, Zagreb University, and hexyl salicylate was used as an irritant to cause an inflammatory reaction. Results have shown that ethanol solution of propolis reduces the number of cells of inflammatory infiltrate and of active macrophages, and has a potent anti-inflammatory effect. A micronucleus test is a reliable indicator of genotoxic damage. Its results showed that ethanol solution of propolis decreases the number of micronuclei in mouse peripheral blood reticulocytes. A conclusion was made that ethanol solution of propolis can safely be utilized in the prevention of psoriasis-related inflammatory changes without causing any toxic effect. Thermography as an inexpensive and simple method has shown the effectiveness and applicability in the research process of inflammation in psoriasis.

Item Type: Thesis (Diploma thesis)
Keywords: psoriasis, hexyl salicylate, ethanolic solution of propolis, inflammation
Supervisor: Oršolić, Nada
Date: 2011
Number of Pages: 58
Subjects: NATURAL SCIENCES > Biology
Divisions: Faculty of Science > Department of Biology
Depositing User: Grozdana Sirotic
Date Deposited: 09 Jun 2014 08:31
Last Modified: 18 Sep 2014 08:40
URI: http://digre.pmf.unizg.hr/id/eprint/2297

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