gabaa receptor α2- subunit gene polymorphism in alcohol-dependent individuals

Stanić, Dijana (2011) gabaa receptor α2- subunit gene polymorphism in alcohol-dependent individuals. Diploma thesis, Faculty of Science > Department of Biology.

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Abstract

GABAA receptors mediate acute and chronic effects of alcohol, including alcohol tolerance, dependence and withdrawal. The results suggested the association of alcoholism with GABRA2 gene encoding the GABAA receptor α2 subunit located on chromosome 4, especially with polymorphisms near the neighboring GABRG1 gene, which encodes the γ1 subunit. The aim of this study was to examine the association of polymorphism rs567926, located between GABRG1 and GABRA2 genes, with alcoholism and related behavior, including smoking, onset of alcohol abuse, aggressive behavior and suicide attempt. We genotyped 335 alcohol-dependent and 230 control subjects from Croatian population. Although the results demonstrated no association of marker rs567926 with alcohol and nicotine addiction or alcoholism-associated behaviour, we found haplotypic association between markers rs567926 and rs279858, and association of some haplotypes with specific phenotypes of alcohol-dependent patients. Further research is needed in order to elucidate the role of GABRA2 gene in alcohol dependence and alcoholism-associated behavior.

Item Type: Thesis (Diploma thesis)
Keywords: alcoholism, GABRA2, GABRG1, genetics, polymorphism, rs567926, haplotype
Supervisor: Švob Štrac, Dubravka
Co-supervisor: Đikić, Domagoj
Date: 2011
Number of Pages: 52
Subjects: NATURAL SCIENCES > Biology
Divisions: Faculty of Science > Department of Biology
Depositing User: Grozdana Sirotic
Date Deposited: 09 Jun 2014 08:59
Last Modified: 18 Sep 2014 10:59
URI: http://digre.pmf.unizg.hr/id/eprint/2301

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