Functional polymorphism of neuronal tryptophan hydroxylase gene in conditions with disturbed serotonergic transmission

Rešetar, Mirta (2011) Functional polymorphism of neuronal tryptophan hydroxylase gene in conditions with disturbed serotonergic transmission. Diploma thesis, Faculty of Science > Department of Biology.

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Abstract

Serotonin is neurotransmitter involved in the regulation of numerous physiological functions and in the etiopathogenesis of various neuropsychiatric conditions. TPH2 (neuronal tryptophan hydroxylase) catalyses the fist, rate-limiting step of brain serotonin synthesis so polymorphisms within the gene for TPH2 can affect overall serotonin levels in the central nervous system. The present work investigated the influence of rs4290270 polymorphism on the development of suicidal behavior, alcoholism, autism, migraine and temporal lobe epilepsy, by comparing allele and genotype distributions between case and control samples. rs4290270 polymorphism displayed significant association with alcoholism type 2 and indicative association with alcoholism type 1 and suicidal behavior in a male population. In cases of autism, migraine and temporal lobe epilepsy no associations were found, but due to certain limitations, it is recommended to repeat the study with more subjects.

Item Type: Thesis (Diploma thesis)
Keywords: genetic association study, serotonin, TPH2, suicidal behavior, alcoholism, autism, migraine, epilepsy
Supervisor: Štefulj, Jasminka
Co-supervisor: Hranilović, Dubravka
Date: 2011
Number of Pages: 37
Subjects: NATURAL SCIENCES > Biology
Divisions: Faculty of Science > Department of Biology
Depositing User: Grozdana Sirotic
Date Deposited: 11 Jun 2014 09:06
Last Modified: 18 Sep 2014 10:04
URI: http://digre.pmf.unizg.hr/id/eprint/2357

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