The role of DRD4 gene polymorphism and activity of MAO enzyme in development of nicotine addiction

Babić, Mirjana (2011) The role of DRD4 gene polymorphism and activity of MAO enzyme in development of nicotine addiction. Diploma thesis, Faculty of Science > Department of Biology.

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Nicotine addiction, related to smoking, develops as a product of social, environmental and genetic factors. Dopaminergic system genes are associated with smoking. Literature shows association and/or lack of association between variable number of tandem repeats (VNTR) polymorphism located in the third exon of D4 dopamine receptor gene (DRD4) and smoking, and reduced or unaltered platelet monoamine oxidase type B (MAO-B) activity in smokers. The aim of this study was to determine whether VNTR in DRD4 gene and MAO-B activity are associated with smoking in Croatian population. Genotyping was done in 565 subjects, while MAO-B activity was determined in 302 subjects. There was no significant difference in distribution of the long and short DRD4 alleles between smokers and non-smokers. MAO-B activity was decreased in male smokers compared to male non-smokers, while in female subjects there were no differences in the activity of this enzyme. The results of this study failed to confirm the hypothesis about the association between DRD4 genotype and smoking, while the hypothesis of the reduced platelet MAO-B activity in smokers was confirmed in male, but not in female subjects because of the small sample

Item Type: Thesis (Diploma thesis)
Keywords: D4 dopamine receptor (DRD4), monoamine oxidase type B (MAO-B), nicotine addiction
Supervisor: Pivac, Nela
Date: 2011
Number of Pages: 59
Subjects: NATURAL SCIENCES > Biology
Divisions: Faculty of Science > Department of Biology
Depositing User: Grozdana Sirotic
Date Deposited: 12 Jun 2014 08:42
Last Modified: 18 Sep 2014 08:34

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