The effect of quercetin in the prevention of osteoporosis in rats

Stanušić, Ena (2011) The effect of quercetin in the prevention of osteoporosis in rats. Diploma thesis, Faculty of Science > Department of Biology.

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Abstract

Quercetin is a flavonol from the flavonoid group and one of the major phytoestrogens present in higher amounts in onions, apples and grapes. The effect of quercetin on osteoporosis and the possibility of its use in preventing the development of osteoporosis in Y-59 rats were investigated. In the first part of the study during 15 days, the animals were intragatricly treated with retinoic acid at dose of 80 mg kg-1 with quercetin (100 mg kg-1) and/or alendronate (40 mg kg-1). In the second part of the study animals were treated during the 15 days only with quercetin and alendronate. The total levels of calcium and phosphorus from the right femur of the animals, and hematological and biochemical parameters were determined. For the assessment of genotoxicity we used comet assay and the micronucleus test. Quercetin showed a beneficial effect on the mineral bone density, while it did not cause any damage in the body. In addition, the results of the present study in rats have given us the hope that quercetin can confer in the prevention of osteoporosis or the reduction of the side effects due to drug-induced osteoporosis, and may be used in humans in the management of osteoporosis in vivo.

Item Type: Thesis (Diploma thesis)
Keywords: quercetin, osteoporosis, retinoic acid, genotoxicity
Supervisor: Oršolić, Nada
Date: 2011
Number of Pages: 55
Subjects: NATURAL SCIENCES > Biology
Divisions: Faculty of Science > Department of Biology
Depositing User: Grozdana Sirotic
Date Deposited: 07 Jul 2014 10:53
Last Modified: 07 Jul 2014 10:53
URI: http://digre.pmf.unizg.hr/id/eprint/2438

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