Serotonin Transporter Gene Polymorphism in Patients with Epilepsy

Prodić, Jelena (2011) Serotonin Transporter Gene Polymorphism in Patients with Epilepsy. Diploma thesis, Faculty of Science > Department of Biology.

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Abstract

Serotonin is a neurotransmiter with a role in many physiological functions and in the etiopathogenesis of different neuropsychiatric disorders. Various studies have revealed the ability of serotonin to affect the generation and the course of epileptic seizures. Serotonin transporter (5-HTT), a transmembrane protein responsible for the removal of 5-HT from the synaptic cleft, is considered to be the main regulator of the 5-HT transmission. The promoter and the second intron of the 5-HTT gene contain functional polymorphisms that affect efficiency of the gene expression. The present work has investigated their association with the temporal lobe epilepsy (TLE). The study included 101 patients suffering from TLE and 155 healthy individuals. Comparison of allelic and genotypic frequencies of promoter (5-HTTLPR) and intron 2 (VNTR-2) polymorphisms, demonstrated no statistically significant difference between the investigated groups. These results indicate that investigated polymorphisms do not play a major role in the etiopathogenesis of TLE in Croatian population, however due to relatively small sample size, their minor effects on the etiopathogenesis of this complex disorder could not be excluded.

Item Type: Thesis (Diploma thesis)
Keywords: association study, temporal lobe epilepsy, polymorphism, serotonin, serotonin transporter
Supervisor: Štefulj, Jasminka
Co-supervisor: Hranilović, Dubravka
Date: 2011
Number of Pages: 37
Subjects: NATURAL SCIENCES > Biology
Divisions: Faculty of Science > Department of Biology
Depositing User: Grozdana Sirotic
Date Deposited: 10 Jul 2014 11:43
Last Modified: 18 Sep 2014 10:00
URI: http://digre.pmf.unizg.hr/id/eprint/2487

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