Social and emotional behaviour in rats after perinatal treatment with serotonin precursor

Čolić, Lejla (2010) Social and emotional behaviour in rats after perinatal treatment with serotonin precursor. Diploma thesis, Faculty of Science > Department of Biology.

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Serotonin (5- hydroxytryptamine, 5HT) is a biologically active amine present in both, brain and peripheral tissues where it serves different physiological functions. 5HT also regulates brain development. Disruption of 5HT metabolic pathway or impairments in its function could represent a base for different bahavioural disorders including autism. During prenatal and early postnatal development, high concentrations of serotonin in blood could inhibit 5HT neuronal growth and differentiation, and so cause anatomical and functional changes in brain. To examine consequences of high blood 5HT concentrations during perinatal development, rats were treated with 5HT precursor, 5HTP (5- hydroxytryptophan, 25mg/kg ) from 13th gestational day till 21st postnatal day. In this study we explored consequences of the mentioned perinatal treatment on cognitive, social and emotional behaviour in rats. Experimental group (treated with 5HTP) and control group (treated with saline solution) of rats were submitted to the battery of tests. We examined learning and cognitive rigidity, locomotor activity, anxiety and exploratory behaviour, sociability, and reaction and habituation to repeated high-frequency sound. Experimental group displayed significantly higher level of locomotion and anxiety, and showed lower sociability and ability to habituate to the repeated high-frequency sound. Learning capacity and cognitive rigidity did not differ between the groups. These results show that the treatment with 5HTP has influenced 5HT-regulated bahaviours, and indicate changes in the central 5HT compartment that occurred during brain development.

Item Type: Thesis (Diploma thesis)
Keywords: 5- hydroxytryptophan, serotonin, rat, behaviour, hyperserotonemia
Supervisor: Hranilović, Dubravka
Date: 2010
Number of Pages: 36
Subjects: NATURAL SCIENCES > Biology
Divisions: Faculty of Science > Department of Biology
Depositing User: Grozdana Sirotic
Date Deposited: 10 Jul 2014 12:00
Last Modified: 18 Sep 2014 08:28

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