Social and emotional behaviour in rats after perinatal treatment with tranylcypromine

Čulig, Luka (2011) Social and emotional behaviour in rats after perinatal treatment with tranylcypromine. Diploma thesis, Faculty of Science > Department of Biology.

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Abstract

Serotonin (5-hydroxytryptamine, 5-HT) is a biologically active amine present in both brain and peripheral tissues where it serves different physiological functions and it also regulates brain development. Disruption of 5-HT metabolic pathway or impairments in its function could represent a base for different behavioral disorders including autism. During prenatal and early postnatal development, high concentrations of serotonin in blood could inhibit 5HT neuronal growth and differentiation and cause anatomical and functional changes in brain. To examine consequences of high blood 5-HT concentrations during perinatal development, rats were treated with monoamine oxidase inhibitor (MAOI), TCP (tranylcypromine, 2mg/kg) from 13th gestational day until 21st postnatal day. In this study we explored consequences of the mentioned perinatal treatment on cognitive, social and emotional behavior in rats. Experimental group (treated with TCP) and control group (treated with saline solution) of rats were submitted to the battery of tests. We examined learning and cognitive rigidity, locomotor activity, anxiety and exploratory behavior, sociability, and reaction and habituation to repeated high-frequency sound. Experimental group displayed significantly lower level of anxiety and cognitive rigidity, and showed higher sociability and exploratory behavior. Levels of locomotor activity did not differ between the groups. These results show that the treatment with TCP has influenced 5-HT-regulated behaviors, and indicate changes in the central 5-HT compartment that occurred during brain development.

Item Type: Thesis (Diploma thesis)
Keywords: tranylpypromine, serotonin, rat, behaviour, hyperserotonemia
Supervisor: Hranilović, Dubravka
Date: 2011
Number of Pages: 39
Subjects: NATURAL SCIENCES > Biology
Divisions: Faculty of Science > Department of Biology
Depositing User: Grozdana Sirotic
Date Deposited: 10 Jul 2014 12:09
Last Modified: 18 Sep 2014 11:36
URI: http://digre.pmf.unizg.hr/id/eprint/2493

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