EGFR gene polymorphism in sporadic colon cancer

Gomaz, Ana (2011) EGFR gene polymorphism in sporadic colon cancer. Diploma thesis, Faculty of Science > Department of Biology.

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Abstract

Colon cancer is the third most common cancer worldwide and the second leading cause of cancer death. The disease is sporadic in approximately 80% of cases, and occurs as a result of genetic changes that lead to development of carcinoma from adenoma. Epidermal growth factor receptor, EGFR, is a tyrosine kinase receptor involved in proliferation, cell survival and differentiation. Increased expression of EGFR is associated with poor prognosis and less differentiated tumors. R521K polymorphism (1562G> A, NCBI | rs 2227983) in EGFR gene is associated with decreased ligand binding and decreased signal transduction in the EGFR pathway. The thesis examined correlation of the R521K polymorphism with susceptibility to sporadic colon cancer and with length of survival in patients. There was no statistically significant association of polymorphism with susceptibility to develope the disease. There was a statistically significant association with the survival of patients with GA or AA genotypes (p = 0.047), especially in patients younger than 55 years (p = 0.006). R521K polymorphism could be a positive prognostic marker in patients with colon cancer, especially in the younger population.

Item Type: Thesis (Diploma thesis)
Keywords: EGFR, R521K, polymorphism, colon cancer, susceptibility, survival
Supervisor: Kapitanović, Sanja
Co-supervisor: Matulić, Maja
Date: 2011
Subjects: NATURAL SCIENCES > Biology
Divisions: Faculty of Science > Department of Biology
Depositing User: Grozdana Sirotic
Date Deposited: 21 Jul 2014 10:47
Last Modified: 23 Sep 2014 12:29
URI: http://digre.pmf.unizg.hr/id/eprint/2531

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