Effects of propofol and N-acetylcystein on oxidative stress in a dog model

Baronica, Robert (2014) Effects of propofol and N-acetylcystein on oxidative stress in a dog model. Doctoral thesis, Faculty of Science > Department of Biology.

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Abstract

The objectives of this study were to investigate the effects of anesthesia with isoflurane or propofol with addition of N-acetylcysteine during open and laparoscopic ovariectomy in bitches on malondialdehyde concentration, total oxidative status and antioxidant capacity. Also, the aim was to investigate possible synergistic effects of propofol and N-acetylcysteine. The study was prospective, randomised and controlled. 61 female dogs were allocated in 6 groups according to surgical technic and type of anesthesia. Blood samples for the analysis were taken after the induction of anesthesia, at the end of the procedure and 24 hours after. High performance liquid chromatography and colorimetric, enzymatic tests were used for the analysis. In most of the groups statistically significant differences in parameters of oxidative stress were not found. However, analysis of statistical differences which were found and observation of positive trends during perioperative period, discerned trend that laparoscopic surgery and anestehsia with propofol could have beneficial effects.

Item Type: Thesis (Doctoral thesis)
Keywords: oxidative stress, propofol, N-acetylcystein, ovariectomy
Supervisor: Bačić, Goran
Co-supervisor: Tonković, Dinko
Date: 2014
Number of Pages: 96
Subjects: NATURAL SCIENCES > Biology
Divisions: Faculty of Science > Department of Biology
Depositing User: Grozdana Sirotic
Date Deposited: 22 Jul 2014 09:55
Last Modified: 23 Sep 2014 08:26
URI: http://digre.pmf.unizg.hr/id/eprint/2534

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