Distribution of Streptococcus pneumoniae serotypes among macrolide-resistant strains

Mohila, Sanja (2011) Distribution of Streptococcus pneumoniae serotypes among macrolide-resistant strains. Diploma thesis, Faculty of Science > Department of Biology.

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Abstract

Streptococcus pneumoniae commonly colonises the nasopharynx of children, and when the host's immunity is impaired it can spread and cause otitis media, sinusitis, pneumonia or even sepsis or meningitis. Antibiotic resistance within Streptococcus pneumoniae represents a major healthcare challenge in many countries. In this study, a total of 165 macrolide-resistant isolates, were obtained from children under 16 years of age in different regions of Croatia (Zagreb, Rijeka, Osijek and Varazdin Regions). The aim of the study was to compare the distribution of the serotypes among resistant strains. The most common serotypes were 19A and 19F. Other serotypes (1, 3, 5, 8, 6A, 6B, 6C, 9, 10, 11, 14, 15, 17 and 18C) were detected with a low frequency.The macrolide-resistance in strains collected in Osijek and Varazdin regions was associated with serotype 19A, and the resistance in strains collected in Rijeka and Zagreb regions was associated with serotype 19F (p<0.01). Serotype coverage for the 7-valent conjugate vaccine in Osijek and Varazdin region is low and emergence of a macrolide-resistant serotype 19A pneumococcal strain not included in the 7-valent conjugate vaccine is detected.

Item Type: Thesis (Diploma thesis)
Keywords: Streptococcus pneumoniae, macrolide resistance, serotype, vaccine
Supervisor: Vraneš, Jasmina
Co-supervisor: Hrenović, Jasna
Date: 2011
Subjects: NATURAL SCIENCES > Biology
Divisions: Faculty of Science > Department of Biology
Depositing User: Silvana Šehić
Date Deposited: 02 Sep 2014 09:27
Last Modified: 18 Sep 2014 09:50
URI: http://digre.pmf.unizg.hr/id/eprint/2579

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