Research of haplotypes HLA-B27 in patients with spondyloarthropathies in Croatian population

Štimac, Davor (2010) Research of haplotypes HLA-B27 in patients with spondyloarthropathies in Croatian population. Diploma thesis, Faculty of Science > Department of Biology.

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Abstract

In this study we analyzed the alleles of 5 HLA microsatellites (D6S248, D6S2674, D6S2811, STR_MICA and D6S273) among HLA-B27 positive, healthy individuals (N=94), patients with psoriatic arthritis (PsA) (N=22) and patients with juvenile spondyloarthropaties (jSpA) (N=29). The most common alleles in all tested groups were: D6S248-291pb, D6S2674-131pb, D6S2811-98pb and STR_MICA-A4 alleles, while at the D6S273 locus, the most common allele among patients with jSpA and controls was D6S273-4 allele and among patients with PsA D6S273-5 allele. The analysis of patients with PsA determined that D6S273-3 allele is associated with an increased risk for the disease, while D6S2811-126pb and D6S273-4 alleles, as well as HLA-B*27/D6S273-4 haplotypic association show a protective role for the development of the disease. A decreased frequency of D6S2674-131pb allele and HLA-B*27/D6S2674-131 and HLA-B*27/D6S2811-98 haplotypic associations was discovered among patients with jSpA which implies their protective role for the development of the disease. On the other hand, a statistically significant increase in frequency was determined for STR_MICA-A9 allele and the HLA-B*27/D6S248-291 haplotypic association which leads to the conclusion that they are involved in the development of jSpA.

Item Type: Thesis (Diploma thesis)
Keywords: microsatellite, haplotype HLA, HLA-B27 gene, psoriatic arthritis, juvenile spondyloarthropathy
Supervisor: Grubić, Zorana
Co-supervisor: Oršolić, Nada
Date: 2010
Number of Pages: 53
Subjects: NATURAL SCIENCES > Biology
Divisions: Faculty of Science > Department of Biology
Depositing User: Silvana Šehić
Date Deposited: 03 Sep 2014 09:41
Last Modified: 16 Feb 2016 13:56
URI: http://digre.pmf.unizg.hr/id/eprint/2600

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