Morphometry of larynkx and proton pump (H+/K+ -ATPASE expression in human larynks

Stevanović, Siniša (2013) Morphometry of larynkx and proton pump (H+/K+ -ATPASE expression in human larynks. Doctoral thesis, Faculty of Science > Department of Biology.

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Abstract

Laryngopharyngeal reflux is quite spread, but still not suffitiently investigated dissease that is at least partly connected to pathogenesis of other laryngeal disseases. It is generally known to be developed by upward recurrence of acid gastric content, but there are some signs that acid can be produced in larynx as well, because of the proton pump activity in the laryngeal mucosa. There is also quite small number of studies about detailed laryngeal morphometry.Theafore the goal of our study was to investigate laryngeal morphometric corelations and to identify the existance of proton pump in different parts of larynx.The presence of proton pump was determined by imunohistochemistry in a group of 50 cadavers and 11 live patients after laryngectomy. Morphometric analysis showed corelation between measured parameters for better understanding of development of laryngeal parts. The presence of proton pump was proved in seromucos glands in laryngeal supraglottic area, but it is also, for the first time, found in human hondrocites of thyroid and epiglottic cartilage.These new findings of proton pump expression open the space for additional research, not only of laryngopharyngeal reflux, but also the pathophysiology of cartilaginous disorders.

Item Type: Thesis (Doctoral thesis)
Keywords: morphometry, larynx, thyroid cartilage, laryngopharyngeal reflux, proton pump
Supervisor: Radić, Radivoje
Date: 2013
Number of Pages: 93
Subjects: BIOMEDICINE AND HEALTH CARE > Clinical Medical Sciences
Divisions: Faculty of Science > Department of Biology
Depositing User: Grozdana Sirotic
Date Deposited: 27 Jan 2014 13:35
Last Modified: 22 Sep 2014 19:39
URI: http://digre.pmf.unizg.hr/id/eprint/268

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