Platelet serotonin in children with attention deficit/ hyperactivity disorder

Petek, Ines (2009) Platelet serotonin in children with attention deficit/ hyperactivity disorder. Diploma thesis, Faculty of Science > Department of Biology.

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Abstract

Attention deficit/ hyperactivity disorder (ADHD) is a psychiatric disorder with unclear neurobiological background, thought to be associated with altered dopaminergic, noradrenergic and serotonergic (5-HT) systems functions. Platelet 5-HT concentration is changed in particular behaviors (aggressive, impulsive) and cognitive disturbances, related to ADHD. The study used platelets as a limited peripheral model of the central 5-HT synaptosomes, since they use, release and metabolize 5-HT similarly as central 5-HT synaptosomes. Platelet 5-HT concentration was determined in groups of children with ADHD and healthy control children, and the possible influence on sex on platelet 5-HT concentration was also evaluated. The results showed the lack of significant differences in platelet 5-HT concentration between boys and girls with ADHD and control boys and girls. No significant sex related differences in platelet 5-HT concentration were found. The findings suggest that ADHD is not associated with altered platelet 5-HT concentration. Peripheral biological marker such as platelet 5-HT is related to specific behaviors or symptoms altered in ADHD, and platelet 5-HT concentration could not be used as a peripheral biological marker of a complex diagnostic entity such as ADHD.

Item Type: Thesis (Diploma thesis)
Keywords: serotonin (5-HT), platelets, ADHD, children
Supervisor: Pivac, Nela
Date: 2009
Number of Pages: 43
Subjects: NATURAL SCIENCES > Biology
Divisions: Faculty of Science > Department of Biology
Depositing User: Silvana Šehić
Date Deposited: 10 Sep 2014 10:28
Last Modified: 10 Sep 2014 10:28
URI: http://digre.pmf.unizg.hr/id/eprint/2692

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