Toksicodynamics of prometryne in mice blood

Kipson, Marina (2009) Toksicodynamics of prometryne in mice blood. Diploma thesis, Faculty of Science > Department of Biology.

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Abstract

Prometryne is a member of triazine herbicide group (s-triazines) which make one of the most common herbicide groups and are persistent in soil and water sediment. The aim of this study was to describe toxicodynamics of prometryne in the mice blood (in vivo) during 24 hour time-period. Mice were given a single acute dose per os and the detection of prometryne blood concentration was done with gas chromatography-mass spectrometry (GCMS) method. Prometryne was detected in all analyzed times over 24 hours with relatively low percentage in contrast to the entry dose. Results indicate a significant statistical difference between sexes until the 4th hour from prometryne oral entry. After 4th hour the concentration of prometryne in male and female mice becomes equal and it is no longer statistically significant. Although prometryne is detected with low concentrations after 24 hours, this shows that it is not completely eliminated from the organism and might build up and increase in total blood concentration.

Item Type: Thesis (Diploma thesis)
Keywords: prometryne, toksicodynamic, blood, triazine
Supervisor: Springer, Oskar
Date: 2009
Number of Pages: 40
Subjects: NATURAL SCIENCES > Biology
Divisions: Faculty of Science > Department of Biology
Depositing User: Silvana Šehić
Date Deposited: 12 Sep 2014 08:40
Last Modified: 12 Sep 2014 08:40
URI: http://digre.pmf.unizg.hr/id/eprint/2732

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