Toxicodynamics of promethryne herbicide in mouse spleen

Majer, Marija (2008) Toxicodynamics of promethryne herbicide in mouse spleen. Diploma thesis, Faculty of Science > Department of Biology.

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A variety of herbicides is discharged into ecological systems as a consequence of human activity. Promethryne is one of the methiltiotriazine herbicides. This selective pesticide of common use is slightly to moderately toxic. It's immunotoxic effects and toxicodynamics have been poorely studied so far. Spleen is one of the target sites of immunotoxic effects caused by pesticides or some carcinogens. Gas chromatography-mass spectrometry assay was applied to detect promethryne concentrations in spleen samples of acutely treated mice after 1st, 6th, 24th and 48th hour post exposure. Bioavailable concentrations of promethryne in spleen were indentified. The spleen bioaccumulation potential was not significant after single oral 375 mg kg-1 (1/10 LD50) dose. Sex differences could not be detected during each kinetic phase, but do indicate sex dependent differences in promethryne metabolic processing. Results of promethryne toxicodynamics analysis in spleen can be applied to risk assessment via alometric scaling from animal to humans.

Item Type: Thesis (Diploma thesis)
Keywords: herbicides, toxicodynamics of promethryne, spleen, alometric scaling, risk assessment
Supervisor: Springer, Oskar
Date: 2008
Number of Pages: 40
Subjects: NATURAL SCIENCES > Biology
Divisions: Faculty of Science > Department of Biology
Depositing User: Silvana Šehić
Date Deposited: 15 Sep 2014 09:54
Last Modified: 16 Feb 2016 14:12

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