Platelet serotonin and suicidality in alcoholic patients

Šimčić, Oliver (2010) Platelet serotonin and suicidality in alcoholic patients. Diploma thesis, Faculty of Science > Department of Biology.

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Abnormal activity of the central serotonergic (5-HT) system is associated with alcoholism, depression, impulsivity, aggression and suicidal behavior. Central serotonergic synaptosomes and platelets share similar biochemical processes, and therefore platelets could be used as easy obtainable peripheral models for studies of particular psychopathologies related to alterations of the central 5-HT. Chronic alcoholic patients are prone to develop suicidal behavior. Suicidal behavior is associated with lower platelet 5-HT concentration in psychiatric patients. The study included 359 male and 90 female alcoholic, medication-free patients, and 425 healthy male and 156 healthy female control subjects. Chronic alcoholic subjects were subdivided according to the sex, comorbid depression, suicidal behavior and suicidal attempts. Platelet 5-HT concentration was significantly lower in chronic alcoholic patients than in healthy subjects, however it did not differ significantly between alcoholic patients with or without suicidal behavior, or between those who tried or did not try to attempt suicide. Therefore, these results suggested that platelet 5-HT concentration could not be used as a peripheral marker of suicidal behavior in alcoholic patients.

Item Type: Thesis (Diploma thesis)
Keywords: platelet serotonin (5-HT), suicidal behavior, suicidal attempts, alcoholic patients
Supervisor: Pivac, Nela
Co-supervisor: Oršolić, Nada
Date: 2010
Number of Pages: 58
Subjects: NATURAL SCIENCES > Biology
Divisions: Faculty of Science > Department of Biology
Depositing User: Silvana Šehić
Date Deposited: 25 Sep 2014 09:23
Last Modified: 25 Sep 2014 09:23

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