Serotonin receptor 1A (5HT-1A) gene polymorphism in patients with temporal lobe epilepsy

Ćalušić, Marija (2011) Serotonin receptor 1A (5HT-1A) gene polymorphism in patients with temporal lobe epilepsy. Diploma thesis, Faculty of Science > Department of Biology.

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Abstract

Epilepsy is a complex disease of the nervous system which occurs due to irregular bursting of electric impulses in the brain and has a broad spectrum of clinical symptoms. Epilepsy is developed through various mechanisms. Frequent causes are disorders and malformations during development, changes in the brain due to various traumas and genetic background. One of the most common types of epilepsy is the temporal lobe epilepsy which is characterised by partial seizures which arrise from one or both temporal lobes. Numerous studies show that serotonin (5-hydroksitryptamine, 5HT), a biogenic monoamine which primarily functions as a neurotransmitter, is involved in epilepsy. It is also involved in regulation of many physiological functions and various forms of behaviours, as well as in etiopathogenesis of diverse psychiatric disorders. Serotonin exerts its action through 18 different receptors, divided into 7 families (5HT-1 – 5HT-7). The largest family are the 5HT-1 receptors which include the 5HT-1A receptor. Research on experimental animals show connection of 5HT-1A receptor in development of epileptic seizures. 5HT-1A receptor gene has several known polymorphisms, mostly single nucleotide polymorphisms (SNPs), which contribute to the receptor heterogeneity. One of the most investigated SNP of this gene is the promotor region polymorphism, C(-1019)G, which was shown to affect gene expression and neurotransmission through 5HT-1A receptor. This research was directed towards the C(-1019)G polymorphism in persons suffering from temporal lobe epilepsy compared to healthy people. No statistically significant differences in distributions of genotypes or allelles were found between these two groups.

Item Type: Thesis (Diploma thesis)
Keywords: serotonin, epilepsy, serotonin receptor 1A, single nucleotide polymorphism C(-1019)G
Supervisor: Čičin-Šain, Lipa
Co-supervisor: Hranilović, Dubravka
Date: 2011
Number of Pages: 38
Subjects: NATURAL SCIENCES > Biology
Divisions: Faculty of Science > Department of Biology
Depositing User: Silvana Šehić
Date Deposited: 25 Sep 2014 10:25
Last Modified: 25 Sep 2014 10:25
URI: http://digre.pmf.unizg.hr/id/eprint/2817

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