The role of chrysin on the histomorphometrical characteristics of osteoporosis caused by retinoic acid in rats

Sašilo, Kristijan (2013) The role of chrysin on the histomorphometrical characteristics of osteoporosis caused by retinoic acid in rats. Diploma thesis, Faculty of Science > Department of Biology.

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Abstract

Disbalance between the increased production of reactive oxygen species and the inadequate activity of the antioxidant system causes oxidative stress. Role of the free radical in pathogenesis of many diseases, including osteoporosis, has been confirmed. Lipid peroxidation is one of the main characteristics of the oxidative stress, and malondialdehyde (MDA) one of its ultimate products, as well as the indicator of free radical production. It has been shown that bee honey (a natural product rich in antioxidant chrysin) has significant effect on prevention of osteoporosis, therefore we decided to investigate the effects of chrysin on body weight, histomorphometrical parameters of bone, calcium and phosphorus contents, as well as on concentrations of MDA and glutathione (GSH) in test animals. Based on the obtained results, we concluded that chrysin displays significant antioxidative and antiosteoporotic activity and that its use could be helpful in preventing osteoporosis and understanding the relationship between the functional diet and health.

Item Type: Thesis (Diploma thesis)
Keywords: osteoporosis, oxidative stress, lipid peroxidation, glutathione, histomorphometrical analysis
Supervisor: Oršolić, Nada
Date: 2013
Number of Pages: 47
Subjects: NATURAL SCIENCES > Biology
Divisions: Faculty of Science > Department of Biology
Depositing User: Silvana Šehić
Date Deposited: 25 Sep 2014 12:07
Last Modified: 25 Sep 2014 12:07
URI: http://digre.pmf.unizg.hr/id/eprint/2826

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