Evaluation of anti-inflammatory and antioxidant effect of quercetin in animal model of psoriasis

Odeh, Dyana (2013) Evaluation of anti-inflammatory and antioxidant effect of quercetin in animal model of psoriasis. Diploma thesis, Faculty of Science > Department of Biology.

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Abstract

Psoriasis is a chronic, inflammatory, proliferative skin disease whose main features are rapid cell proliferation, differentiation, lack of keratin production, redness and desquamation all on which the histopathological analysis of the epidermis is based on. The aim of this study was to apply an infrared camera that records the changes in body temperature and the development of inflammation in animal models of psoriasis, and based on these parameters record the antioxidant and anti-inflammatory effects of quercetin. Experiments involving histopathological and biochemical analysis, monitoring oxidative stress parameters and the application of infrared cameras. The total numbers of inflammatory cells, as well as the differential analysis of the cells both showed a decrease in cell numbers distinctively of lymphocytes, which proved the antiproliferative and anti-inflammatory properties of quercetin. The positive effect of quercetin is not only related to inflammatory cell infiltration but also a much lower spreading index of macrophages in the abdominal cavity, and the explicit apoptotic activity of quercetin. The monitoring of oxidative stress markers in psoriasis also demonstrated the clear antioxidant activity of quercetin.

Item Type: Thesis (Diploma thesis)
Keywords: inflammation, oxidative stress, reactive oxygen species, cytokines, flavonoids
Supervisor: Oršolić, Nada
Date: 2013
Number of Pages: 74
Subjects: NATURAL SCIENCES > Biology
Divisions: Faculty of Science > Department of Biology
Depositing User: Silvana Šehić
Date Deposited: 26 Sep 2014 10:11
Last Modified: 26 Sep 2014 10:11
URI: http://digre.pmf.unizg.hr/id/eprint/2832

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