IL-1 β gene polymorphisms in tumorigenesis of sporadic colon cancer

Ćurković, Veronika (2013) IL-1 β gene polymorphisms in tumorigenesis of sporadic colon cancer. Diploma thesis, Faculty of Science > Department of Biology.

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Abstract

Colon cancer is the third most common cancer worldwide and the second leading cause of cancer death. It occurs as a consequence of multistep process in which colorectal carcinoma develops from adenoma, as a result of mutations accumulation. Existing prognostic markers give only partial information about course and outcome of this disease, so there is a need for discovery of novel disease-related diagnostic and prognostic molecular markers. One of these new markers could be also cytokine IL-1β. A number of studies have reported increased IL-1β concentration in different cancer types. Previous studies have shown association between -31 T/C and +3954 C/T IL-1β gene polymorphisms with higher expression and elevated IL-1β serum levels. The aim of this study was to investigate the correlation between these two IL-1β gene polymorphisms and susceptibility to disease and survival of patients suffering from sporadic colorectal cancer. Our results showed the correlation between polymorphisms +3954 C/T and survival of patients with colon cancer.

Item Type: Thesis (Diploma thesis)
Keywords: IL-1β, gene polymorphism, sporadic colon cancer, survival
Supervisor: Matulić, Maja
Date: 2013
Number of Pages: 43
Subjects: NATURAL SCIENCES > Biology
Divisions: Faculty of Science > Department of Biology
Depositing User: Silvana Šehić
Date Deposited: 26 Sep 2014 11:10
Last Modified: 26 Sep 2014 11:10
URI: http://digre.pmf.unizg.hr/id/eprint/2839

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