The correlation between matrix metalloproteinase-2 and p63 expression and peritumoral retraction clefting in breast carcinoma

Lež, Cvjetko (2013) The correlation between matrix metalloproteinase-2 and p63 expression and peritumoral retraction clefting in breast carcinoma. Doctoral thesis, Faculty of Science > Department of Biology.

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Abstract

In this study we analyzed the presence and correlation of peritumoral retraction clefting and the expression of matrix metalloproteinase-2 (MMP-2) and p63 in invasive ductal breast carcinoma. The occurrence of peritumoral clefting and expression of MMP-2 and p63 was also correlated to patient age, tumor size and histological grade, axillary lymph node status, TNM stage, stage of the disease and the expression of Her2/neu, estrogen and progesterone receptors. The results show a statistically significant higher occurrence of peritumoral clefting in older patients (p=0,010) and larger tumors (p=0,018). The expression of MMP-2 did not show statistically significant correlation to peritumoral clefting nor to other parameters. p63 expression was found only in one grade III carcinoma. p63 expression in the myoepithelial cells of the surrounding normal breast tissue and the lack in carcinomas showing peritumoral clefting, indicates the correlation between the loss of myoepitelial cells and the occurrence of peritumoral retraction clefting.

Item Type: Thesis (Doctoral thesis)
Keywords: breast carcinoma, peritumoral retraction clefting, matrix metalloproteinase-2, p63
Supervisor: Krušlin, Božo
Date: 2013
Number of Pages: 89
Subjects: NATURAL SCIENCES > Biology
Divisions: Faculty of Science > Department of Biology
Depositing User: Silvana Šehić
Date Deposited: 29 Sep 2014 09:55
Last Modified: 29 Sep 2014 09:55
URI: http://digre.pmf.unizg.hr/id/eprint/2852

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