Phylostratigraphic analysis of the macroevolutionary history of organ systems in animals

Šestak, Martin Sebastijan (2013) Phylostratigraphic analysis of the macroevolutionary history of organ systems in animals. Doctoral thesis, Faculty of Science > Department of Biology.

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Abstract

Major aim of this thesis was to reconstruct macroevolutionary history of several vertebrate organ systems using a genomic phylostratigraphy and related methods. Organ systems represent morphological phenotype and I first demonstrated the applicability of phylostratigraphic approach on morphological evolution by showing the validity of the model of genome growth through the mechanism of constructional selection and I demonstrated the robustness of transcriptome age index during vertebrate embryonic development. In the next step I applied tested approaches to examine the macroevolutionary trajectories of head sensory organs and central nervous system during zebrafish (Danio rerio) ontogeny. Obtained results agree with the Butler’s serial transformation hypothesis and they revealed a deep evolutionary history and the stepwise evolution of head sensory organs and vertebrate brain. Taken together this study showed that phylostratigraphic approach can simultaneously detect adaptive changes in multiple organ systems of vertebrates and that the macroevolution of organ systems involved periods rife with morphological innovations and recruitment of novel genes.

Item Type: Thesis (Doctoral thesis)
Keywords: genomic phylostratigraphy, evolution, organ systems, zebrafish Danio rerio, genome evolution, evolutionary developmental biology (Evo-Devo)
Supervisor: Domazet-Lošo, Tomislav
Date: 2013
Number of Pages: 157
Subjects: NATURAL SCIENCES > Biology
Divisions: Faculty of Science > Department of Biology
Depositing User: Silvana Šehić
Date Deposited: 29 Sep 2014 10:01
Last Modified: 29 Sep 2014 10:01
URI: http://digre.pmf.unizg.hr/id/eprint/2853

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