Genome-wide association study of human body fatness in the population of the island of Vis

Tomas, Željka (2014) Genome-wide association study of human body fatness in the population of the island of Vis. Doctoral thesis, Faculty of Science > Department of Biology.

[img]
Preview
PDF
Language: Croatian

Download (2MB) | Preview

Abstract

Obesity is one of the main risk factors for cardiovascular diseases, diabetes and cancer. Although the rise in the prevalence of obesity was mainly driven by the environmental factors, there are significant interindividual differences in the response to modern lifestyle, partly due to different genetic predisposition. In order to investigate genetic and environmental factors contributing to the incidence of obesity, genome-wide association analysis of body fatness, body mass index and waist circumference was conducted in the isolated population of Vis. Polymorphism rs4954723 located near NXPH2 gene was statistically significantly associated with body mass index and waist circumference. None of the statistically or nominally associated polymorphisms were confirmed in the replication study. Environmental factors which were significant predictors of body fatness were sex, diet and smoking status, for body mass index only diet and smoking status, while for waist circumference diet, smoking status, physical activity and socioeconomic status were significant.

Item Type: Thesis (Doctoral thesis)
Keywords: obesity, genome-wide association study, bioelectrical impedance, isolated population, Vis
Supervisor: Smolej Narančić, Nina
Date: 2014
Number of Pages: 185
Subjects: NATURAL SCIENCES > Biology
Divisions: Faculty of Science > Department of Biology
Depositing User: Silvana Šehić
Date Deposited: 29 Sep 2014 11:17
Last Modified: 29 Sep 2014 11:17
URI: http://digre.pmf.unizg.hr/id/eprint/2857

Actions (login required)

View Item View Item

Nema podataka za dohvacanje citata