Influence of environmental factors on multixenobiotic resistance mechanism in earthworm Eisenia fetida, Savigny

Babić, Sanja (2013) Influence of environmental factors on multixenobiotic resistance mechanism in earthworm Eisenia fetida, Savigny. Diploma thesis, Faculty of Science > Department of Biology.

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Abstract

Multixenobiotic resistance mechanism (MXR) is cellular detoxification mechanism mediated by the activity of ATP-binding cassette (ABC) transporters. The main representatives of MXR mechanism are P-glycoprotein (P-gp; ABCB1), multidrug resistance associated proteins (MRP; ABCC1-5) and breast cancer resistance (BCRP; ABCG2) protein. These transmembrane efflux proteins are present in all organisms and represent a first line defence mechanism, by extrusion endogenous chemicals, xenobiotics, including man-made chemicals out of the cell (organism), thus preventing toxic effect. Bisphenol A is one of the highest volume chemicals produced worldwide because of their use in the manufacture of polycarbonate plastic. In this study was for the first time identified presence of MXR efflux activity, determined the partial sequence of P-gp/ABCB1 and defined impact of bisphenol A and polluted snow samples on detoxification mechanisms in earthworm Eisenia fetida.

Item Type: Thesis (Diploma thesis)
Keywords: ABC transport proteins, P-glycoprotein (P-gp), bisphenol A
Supervisor: Sauerborn Klobučar, Roberta
Co-supervisor: Pavlica, Mirjana
Date: 2013
Number of Pages: 65
Subjects: NATURAL SCIENCES > Biology
Divisions: Faculty of Science > Department of Biology
Depositing User: Silvana Šehić
Date Deposited: 29 Sep 2014 12:12
Last Modified: 29 Sep 2014 12:12
URI: http://digre.pmf.unizg.hr/id/eprint/2859

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