Regulation of Plekhm1 in autophagy by phosphorylation

Gubaš, Andrea (2013) Regulation of Plekhm1 in autophagy by phosphorylation. Diploma thesis, Faculty of Science > Department of Biology.

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Abstract

Autophagy is a process involved in membrane trafficking of proteins, organelles, pathogens and aggregates to lysosomes for degradation. Autophagy consists of large molecular machinery, regulated by numerous mechanisms. The process of macroautophagy requires the de novo formation of a double membrane layer that surrounds the target material, seals and eventually fuses with the lysosome. One of the key regulators in autophagy is mammalian target of rapamycin, mTOR. Previous studies showed the involvement of a protein called Pleckstrin homology domain-containing family M member 1, Plekhm1 in osteopetrosis, a disease affecting bone resorbtion. Our unpublished data suggests that Plekhm1 is involved in later stages of autophagy. Also, our data suggests that Plekhm1 interacts with Rab7 and LC3 proteins, which are indicatiors of late phase autophagy. Here, we give a brief insight into Plekhm1 regulation and highlight novel interactions with proteins involved in autophagy.

Item Type: Thesis (Diploma thesis)
Keywords: macroautophagy, Plekhm1, mTOR, interactions, phos-tag
Supervisor: Đikić, Ivan
Date: 2013
Number of Pages: 42
Subjects: NATURAL SCIENCES > Biology
Divisions: Faculty of Science > Department of Biology
Depositing User: Silvana Šehić
Date Deposited: 30 Sep 2014 08:21
Last Modified: 30 Sep 2014 08:21
URI: http://digre.pmf.unizg.hr/id/eprint/2868

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