The role of catechol-O-methyltransferase and dopamine transporter gene polymorphisms in alcoholism

Nižić, Petra (2013) The role of catechol-O-methyltransferase and dopamine transporter gene polymorphisms in alcoholism. Diploma thesis, Faculty of Science > Department of Biology.

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Abstract

Alcoholism is complex psychiatric disorder which develops as a product of genetic and environmental factors and their interaction. Although genes of the dopaminergic system are associated with alcoholism, studies show contradictory data on association of alcoholism with catechol-O-methyltransferase (COMT) Val108/158Met polymorphism or with variable number of tandem repeats polymorphism in the 15th exon of dopamine transporter gene (DAT1). The aim of this study was to determine whether polymorphisms in COMT and DAT1 genes are associated with alcoholism and alcoholism-related phenotypes in Croatian population. The study included 376 subjects with alcohol dependence and 397 control subjects. There was no significant difference in the frequency of the COMT and DAT1 genotypes and alleles between alcoholics and healthy subjects. The results failed to confirm the hypothesis of the association between alcoholism and COMT and DAT1 polymorphisms, but identified their association with beginning of the excessive alcohol use. Also, a relationship between COMT polymorphism and suicidal behavior and suicide attempt was found.

Item Type: Thesis (Diploma thesis)
Keywords: dopaminergic system, alcoholism-related phenotypes, beginning of the excessive alcohol use, suicide attempt, suicidal behavior
Supervisor: Pivac, Nela
Co-supervisor: Hranilović, Dubravka
Date: 2013
Number of Pages: 57
Subjects: NATURAL SCIENCES > Biology
Divisions: Faculty of Science > Department of Biology
Depositing User: Silvana Šehić
Date Deposited: 30 Sep 2014 09:16
Last Modified: 30 Sep 2014 09:16
URI: http://digre.pmf.unizg.hr/id/eprint/2874

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