Macrophage centers in fish liver-histological biomarkers of stress

Krbavčić, Martina (2009) Macrophage centers in fish liver-histological biomarkers of stress. Bachelor's thesis, Faculty of Science > Department of Biology.

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In the last hundred years there was a large increase in enviromental pollution. Fish come in contact with pollutants, of which a large part bioaccumulate in their body and are therefore believed to be suitable as biological indicators of pollution. Melano-macrophage centers are clusters of pigmented cells that can normally be found as a part of hematopoetic tissue in spleen and kidney but also in the fish liver. The appearance of melano-macrophage centers can vary between species, organs and physiological conditions within the same species. There we can find three basic types of pigments: melanin, lipofuscin and haemosiderin, but the origin and biochemical role of those pigments varies and is not yet fully known. It is assumed that the primary function of those centers is destruction, detoxification and recycling of endogenous and exogenous cellular material. Apart from being "garbage collectors," melano-macrophage centers are considered as phylogenic precursors of germ centers of lymphatic nodes. It is experimentally shown that melano-macrophage centers, found in liver, are biologically suitable to be used as indicators of stress, but it is necessary to take into consideration variable parameters such as age, sex, sexual maturity and environmental factors.

Item Type: Thesis (Bachelor's thesis)
Supervisor: Lacković Venturin, Gordana
Date: 2009
Number of Pages: 18
Subjects: NATURAL SCIENCES > Biology
Divisions: Faculty of Science > Department of Biology
Depositing User: Silvana Šehić
Date Deposited: 01 Oct 2014 12:38
Last Modified: 16 Feb 2016 14:06

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