Paralogs of aminoacyl-tRNA synthetases

Radman, Inja (2009) Paralogs of aminoacyl-tRNA synthetases. Bachelor's thesis, Faculty of Science > Department of Biology.

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Abstract

Aminoacyl-tRNA synthetases are one of the key enzymes in protein biosynthesis and one of the evolutionary oldest enzymes as well. By analyses of their homologic sequences and protein structures, the existance of a wide spectrum of socalled truncated paralogs, which have mostly functionaly diverged from their originals into several different new pathways, has been shown. In this work a critical review of almost all groups of determined paralogs has been made. Also, function, structure and evolution of the most interesting ones has been established and commented. Paralogs have been divided into two larger subgroups based on their homology characteristics, depending on the homologous catalytic domain possesion. A special emphasis has been put on recently discovered methanogenic seryl-tRNA synthetases paralogs, whose detailed biochemical and structural analyses have just been in progress.

Item Type: Thesis (Bachelor's thesis)
Supervisor: Weygand-Đurašević, Ivana
Date: 2009
Number of Pages: 24
Subjects: NATURAL SCIENCES > Biology
Divisions: Faculty of Science > Department of Biology
Depositing User: Silvana Šehić
Date Deposited: 02 Oct 2014 09:00
Last Modified: 16 Feb 2016 11:34
URI: http://digre.pmf.unizg.hr/id/eprint/2899

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