The role of KIR genes in hematopoietic stem cell transplantation

Burek Kamenarić, Marija (2014) The role of KIR genes in hematopoietic stem cell transplantation. Doctoral thesis, Faculty of Science > Department of Biology.

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Abstract

Killer cell immunoglobulin-like receptors (KIR) are family of inhibitory and activatory receptors expressed on natural killer cells (NK) with the basic role of regulation the NK cell activity. KIRs have influence on the hematopoietic stem cell transplantation (HSCT) outcome and are responsible for generating alloreactive NK cells. To explore the KIR gene role in HSCT, we performed the basic investigation of gene polymorphisms and KIR gene, haplotype and genotype frequencies in the group of healthy unrelated individuals (N=125) that represents the Croatian population and serve as a control group in the further studies. The role of KIR genes in HSCT in terms of disease free survival, the intensity of GvHD and chimerism was evaluated by retrograde analyses of 111 patients and their related and unrelated donors. The results showed that the HLA-C ligands and the donor-recipient KIR genotypes have major influence on the survival and GvHD effect, while there is no effect on achieving full chimerism after HSCT.

Item Type: Thesis (Doctoral thesis)
Keywords: KIR genes, NK cells, Croatian population, Haematopoietic stem cell transplantation, GvHD, survival, chimerism
Supervisor: Žunec, Renata
Date: 2014
Number of Pages: 161
Subjects: NATURAL SCIENCES > Biology
Divisions: Faculty of Science > Department of Biology
Depositing User: Silvana Šehić
Date Deposited: 02 Oct 2014 10:06
Last Modified: 02 Oct 2014 10:06
URI: http://digre.pmf.unizg.hr/id/eprint/2902

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