Yeast ageing

Domitrović, Lidija (2009) Yeast ageing. Bachelor's thesis, Faculty of Science > Department of Biology.

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Abstract

The main goal of the study is to systematically describe ageing process of budding yeast, Saccharomyces cerevisiae. There are several mechanisms of ageing analysed up to now on yeast. Sir2 (Silent Information Regulator Two proten ) is considered as the most important protein in this process. It is involved in both, replicative and chronological ageing of yeast and presents a link between the nutritional state and the regulation of the protein syntesis; it reacts to [NAD]/[NADH] ratio and supress the rRNA shyntesis during calorie restriction. On the other side, signalling pathways involving protein kinase A, TOR and Sch9 are connected with regulation of antioxidative protection during diauxic shift. In conclusion, ageing process in yeast is not determined, but it depends on living conditions and genetic background. Many processes involved in ageing are still unknown. More careful analysis of age-associated phenotypes and related mechanisms will extend research in the field of budding yeast ageing.

Item Type: Thesis (Bachelor's thesis)
Supervisor: Matulić, Maja
Date: 2009
Number of Pages: 9
Subjects: NATURAL SCIENCES > Biology
Divisions: Faculty of Science > Department of Biology
Depositing User: Silvana Šehić
Date Deposited: 03 Oct 2014 09:19
Last Modified: 03 Oct 2014 09:19
URI: http://digre.pmf.unizg.hr/id/eprint/2915

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