Centrioles, centrosomes, and cilia in health and disease

Vidan, Nikolina (2010) Centrioles, centrosomes, and cilia in health and disease. Bachelor's thesis, Faculty of Science > Department of Biology.

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Abstract

Centrioles are barrel-shaped structures in matrix of protein (pericentriolar material), which form a core of centrosomes. They are important for forming cilia and flagella, as well. Following Theodor Boveri's idea of link between centrioles and human cancer, scientists are exploring that possibility and trying to find out details of basic mechanisms in centrosome and link with other diseases. Human diseases resulting from centriole aberrations reflect defects in centriole biogenesis, centrosome structure, function and positioning, or the formation and maintenance of cilia and flagella. Centrosome amplification is common feature of cancer cells driving genetic instability and tumorigenesis. Revealing oncogen mutations and tumor supressor genes can be useful in dignostic and treatment. Every finding in this area answers the questions, often asking new ones, but it is always a step forward to cure for tumors and their early discovery.

Item Type: Thesis (Bachelor's thesis)
Supervisor: Besendorfer, Višnja
Date: 2010
Number of Pages: 11
Subjects: NATURAL SCIENCES > Biology
Divisions: Faculty of Science > Department of Biology
Depositing User: Silvana Šehić
Date Deposited: 06 Oct 2014 09:51
Last Modified: 06 Oct 2014 09:51
URI: http://digre.pmf.unizg.hr/id/eprint/2932

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