The role of lipids in lysosome dysfunction and the pathogenesis of neurodegenerative diseases

Kveštak, Daria (2010) The role of lipids in lysosome dysfunction and the pathogenesis of neurodegenerative diseases. Bachelor's thesis, Faculty of Science > Department of Biology.

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Abstract

Lysosomes are the primary catabolic compartments of eukaryotic cells. Two classes of proteins are essential for the lysosome function: lysosomal hydrolases and integral lysosomal membrane proteins. Lysosomes are involved in various physiological processes, such as cholesterol homeostasis, plasma membrane repair, pathogen defence, cell death and cell signalling. Lysosomal storage disorders (LSD) are mainly caused by the defective activity of lysosomal proteins, which results in the intra-lysosomal accumulation of undegraded metabolites. There is increasing evidence that lysosomes are also involved in the pathogenesis of a variety of neurodegenerative diseases, such as Alzheimer’s disease, Parkinson’s disease and Huntington’s disease. Endosomal/lysosomal dysfunction is caused by altered lipid metabolism. It is hypothesized that abnormal protein degradation and deposition caused by endosomal/lysosomal dysfunction may be the primary trigger of age-related neurodegeneration. In this review, the structure and function of lysosomes, the role of abnormal lipid metabolism in relation to aberrant endosomal/lysosomal function and the relationship between lysosome dysfunction and various neurodegenerative diseases is described.

Item Type: Thesis (Bachelor's thesis)
Supervisor: Katušić Hećimović, Silva
Co-supervisor: Hranilović, Dubravka
Date: 2010
Number of Pages: 14
Subjects: NATURAL SCIENCES > Biology
Divisions: Faculty of Science > Department of Biology
Depositing User: Silvana Šehić
Date Deposited: 06 Oct 2014 11:04
Last Modified: 06 Oct 2014 11:04
URI: http://digre.pmf.unizg.hr/id/eprint/2945

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