Programmed cell death in protozoa

Jantol, Nela (2011) Programmed cell death in protozoa. Bachelor's thesis, Faculty of Science > Department of Biology.

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Over the past 10-15 years, considerable progress has been made in understanding how some of programmed cell death in parasitic protozoa may influence their biology and their interactions with hosts and vectors. The appereance of markers that show apoptosis or autophagy during certain processes and functional evidence support the view that this programmed cell death plays an important role in the lifestyle of parasitic protozoans. In contrast, the effect of parasitic necrosis of the parasite-host interactions and whether it can occur in a regulated manner as described in metazoa is still unknown. Now there is good evidence that the density of individual trypanosomatids and apicomplexan parasites correlates with the appearance of markers of programmed cell death. It should be noted, however, that definitive proof of the concept of regulation of parasite density by parasite apoptosis is still lacking, especially in vivo. Another common theme that appears from these examples is that autophagy is involved in differentiation of parasitic protozoans. In addition, autophagy and autophagic cell death are common responses when the parasites encounter environmental stress. It has become clear that autophagy in parasitic protozoa, as in metazoan, primarily promotes survival, but can be converted to a form of programmed cell death if environmental conditions exceed the capacity of cells. Although we are far from understanding these processes fully, apoptosis and autophagy are essential for the parasitic protozoa and interactions with their hosts and vectors. A detailed knowledge of the underlying molecular mechanism might open the possibility to combat protozoan parasites efficiently by promoting their own death pathways.

Item Type: Thesis (Bachelor's thesis)
Supervisor: Matoničkin Kepčija, Renata
Date: 2011
Number of Pages: 13
Subjects: NATURAL SCIENCES > Biology
Divisions: Faculty of Science > Department of Biology
Depositing User: Silvana Šehić
Date Deposited: 07 Oct 2014 11:01
Last Modified: 07 Oct 2014 11:01

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