Warburg effect: cancer cells metabolism

Križnik, Bojana (2011) Warburg effect: cancer cells metabolism. Bachelor's thesis, Faculty of Science > Department of Biology.

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Abstract

One of the first studies on the energy metabolism of tumors was carried out in 1922, in the laboratory of Otto Warburg. He established that cancer cells exhibited a specific metabolic pattern, characterized by a shift from respiration to fermentation, which has been later named the Warburg effect, and that this is the main cause why normal cells become tumor cells. Here cells maintain a high glycolytic rate even in conditions of adequate oxygen supply, and accumulate large amounts of lactate. This seems to be important in immortalization and transformation of cell as it renders cells resistant to oxidative stress and adaptive to hypoxic condition. Considerable work has been done since Warburg first discovered this phenomenon, deepening our understanding of the process, with consequences for diagnosis and therapy, but still Warburg effect is not yet completely understood. This review presents facts and perspectives on the Warburg effect for the 21st century.

Item Type: Thesis (Bachelor's thesis)
Supervisor: Gruić Sovulj, Ita
Date: 2011
Number of Pages: 14
Subjects: NATURAL SCIENCES > Biology
Divisions: Faculty of Science > Department of Biology
Depositing User: Silvana Šehić
Date Deposited: 07 Oct 2014 12:07
Last Modified: 16 Feb 2016 13:57
URI: http://digre.pmf.unizg.hr/id/eprint/2973

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