Arginylation as a posttranslational protein modification

Cvrtila, Adam (2012) Arginylation as a posttranslational protein modification. Bachelor's thesis, Faculty of Science > Department of Biology.

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Arginylation is a tRNA-dependent posttranslational modification in which arginine is transfered from tRNA molecule mostly onto a amino group of a specific aminoacid of various proteins. Reaction, that does not require hydrolisis of ATP, is catalayzed by enzime arginiltransferase (ATE1). ATE1 is an enzyme that is highly conserved in eukaryotes and no other arginiltransferase exists, but in higher eukaryotes, there are multiple isoforms of ATE1 that are formed by alternative splicing. This paper briefly shows why is the activity of this enzyme essential for cells viability in vast majority of eukaryotic organisms, on which physiological processeses arginylation has an impact and how it affects physiological processes of individual organisms. A lot is still unknown about this postttransalational modification, but we can conclude that it has an important role as a biological regulator.

Item Type: Thesis (Bachelor's thesis)
Supervisor: Mildner, Boris
Date: 2012
Number of Pages: 16
Subjects: NATURAL SCIENCES > Biology
Divisions: Faculty of Science > Department of Biology
Depositing User: Silvana Šehić
Date Deposited: 14 Oct 2014 10:00
Last Modified: 14 Oct 2014 10:00

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