The RAPD method and its application in studies of genotoxicity and carcinogenesis

Ćosić, Marija (2012) The RAPD method and its application in studies of genotoxicity and carcinogenesis. Bachelor's thesis, Faculty of Science > Department of Biology.

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In order to detect genome damage caused by harmful substances from the environment, many methods which enable fast overview of the DNA molecules of exposed organisms have been developed. Among them is the RAPD (random amplified polymorphic DNA) method, which is used frequently because it is simple, efficient and quick. Apart from genome-toxicity related research, RAPD is also used in the study of carcinogenesis and in the populationgenetic studies. The main characteristics of the RAPD method and the areas of its application were specified in this paper. The disadvantages of the method and the ways of its improvement were shown, along with the comparison of the method with other methods used nowadays. After the necessary optimization, this method could be safe and precise indicator of the genome changes , and combined with other methods it gives a clear insight into moleculargenetic events.

Item Type: Thesis (Bachelor's thesis)
Supervisor: Pavlica, Mirjana
Date: 2012
Number of Pages: 15
Subjects: NATURAL SCIENCES > Biology
Divisions: Faculty of Science > Department of Biology
Depositing User: Silvana Šehić
Date Deposited: 14 Oct 2014 10:30
Last Modified: 14 Oct 2014 10:30

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