Calprotectin values and the course of juvenile spondyloarthropathies

Naletilić, Kim (2013) Calprotectin values and the course of juvenile spondyloarthropathies. Diploma thesis, Faculty of Science > Department of Biology.

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Abstract

Juvenile spondyloarthropathies are a group of chronic inflammatory disease, in which the peripheral joints, where the tendon attached to the bone, and joints of the pelvis and spine, are affected. Spondyloarthropathies are frequently associated with chronic inflammatory bowel disease. Calprotectin, protein commonly found in neutrophils, is one of the major proteins of the inflammatory response and defense against pathogens. Studies have shown that faecal calprotectin is a promising marker for monitoring the activities of inflammatory bowel disease and the success of therapy. The aim of this study was to determine if calprotectin could serve to predict and monitor the course of disease in patients with juvenile spondyloarthropathies. For this purpose, two methods were used for the detection of calprotectin in faeces, polyclonal ELISA Calprest kit and monoclonal EliA Calprotectin automated method. The results show a higher level of correlation between calprotectin, obtained by the first method, with other parameters of inflammation (erythrocyte sedimentation rate and C-reactive protein). However, based only on our results, faecal calprotectin can not yet be used as adequate biomarker in predicting the course of juvenile spondyloarthropathies.

Item Type: Thesis (Diploma thesis)
Keywords: arthritis, spondyloarthropathies, inflammation, calprotectin
Supervisor: Harjaček, Miroslav
Co-supervisor: Galov, Ana
Date: 2013
Number of Pages: 55
Subjects: NATURAL SCIENCES > Biology
Divisions: Faculty of Science > Department of Biology
Depositing User: Silvana Šehić
Date Deposited: 14 Oct 2014 11:47
Last Modified: 14 Oct 2014 11:47
URI: http://digre.pmf.unizg.hr/id/eprint/3047

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