Mechanisms of B-cell lymphoma development

Vukušić, Kruno (2013) Mechanisms of B-cell lymphoma development. Bachelor's thesis, Faculty of Science > Department of Biology.

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Abstract

Mechanisms that control normal B-cell differentiation and activation are frequently disrupted in lymphoma cells which in the end leads to their unlimited growth and survival. B cells are particulary prone to malignant transformation because processes that normally create imunoglobulin diversity, which is necessary for normal imunnologic response, often can cause chromosomal translocations and oncogenic mutations which include strong promoters of Ig genes, tumor–supressor genes, and oncogenes. Such aberations often lead to block in differentiation, prevention of apotosis and/or promotion of proliferation which can represent first oncogenic hit in B-cell transformation. In addition, most of B-cell lymphoma depend on expression of a BCR for their survival. In some lymphomas antigen activation of lyphoma cells through BCR signalling snd specific factors from the microenviroment are equally important in tumorogenesis. Reserach and development of funtional and structural genomics greatly improved understanding of mechanisms involved in B-cell lymphoma pathogenesis. Discovery of many signalling pathways which are aberrant in B cell lymphomas, leading to constitutive activation of many prosurvival pathways are now known. In addition, such research showed that B-cell lymhoma can be classified by their cell of origin because transformed cells often resemble normal stages of B-cell differentiation by immunophenotypic and genetic characteristics. In conclusion, development od field of genomics could lead to better understanding of mechanisms that drive B-cell lymphoma pathogenesis, all for one cause - efficient lymphoma therapies.

Item Type: Thesis (Bachelor's thesis)
Supervisor: Korać, Petra
Date: 2013
Number of Pages: 31
Subjects: NATURAL SCIENCES > Biology
Divisions: Faculty of Science > Department of Biology
Depositing User: Silvana Šehić
Date Deposited: 14 Oct 2014 12:36
Last Modified: 14 Oct 2014 12:36
URI: http://digre.pmf.unizg.hr/id/eprint/3052

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