Metastatis of cancer cells

Dodig, Helena (2013) Metastatis of cancer cells. Bachelor's thesis, Faculty of Science > Department of Biology.

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Cancer is a disease in which somatic cells multiplicate uncontrollably due to disfunctional regulation mechanisms. A malignant tumor is capable of invading into adjacent tissues and may be capable of spreading to distant tissues through blood and lymph vessels. The process by which tumor cells from a primary site invade and migrate to other parts of the body is called metastasis. Tumor cells undergo several major steps during metastasis: invasion, intravasation, transport, extravasation, and metastatic colonization. Metastatic colonization cannot be successful without the formation of new blood vessels from pre-existing ones in a proces called angiogenesis. Each of these events is driven by the acquisition of genetic and epigenetic alterations within tumor cells and the co-option of nonneoplastic stromal cells. Metastases selectively colonize specific organs because of a ‘match’ between the migrating tumor cell and a suitable environment. As the bloodstream is the predominant means of long-distance transport and tumor cells can easily get stuck in the vasculature, organs in close proximity are likely to be main sites of metastasis for a particular primary tumor. On the contrary, the destination of metastasized cells can be genetically influenced by interactions between receptors lining the capillaries in certain a organ and tumor cells. Basic research findings have helped develop two new most promising therapies: gene and anti-angiogenic therapy. Developing new techniques which will target protein products of genes that are associated with primary tumor growth and risk of metastasis could give us hope of managing cancer.

Item Type: Thesis (Bachelor's thesis)
Supervisor: Marijanović, Inga
Date: 2013
Number of Pages: 15
Subjects: NATURAL SCIENCES > Biology
Divisions: Faculty of Science > Department of Biology
Depositing User: Silvana Šehić
Date Deposited: 14 Oct 2014 12:40
Last Modified: 14 Oct 2014 12:40

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