Inflammation and tumor

Rođak, Edi (2013) Inflammation and tumor. Bachelor's thesis, Faculty of Science > Department of Biology.

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Abstract

Peyton Rous came to conclusion that small, permanent damages to cells produce initiation points for tumor growth. [4] Those initiation points still need a second stimulus which will promote them into growth. Frequently, that stimulus is inflammation. Inflammation process produces reactive radicals which damage nearby tissue. Promoted cells start growing and producing cytokines and chemokines which are “hormones” of immune system. With control of them, tumor starts recruiting other immune cells which it uses for regulation of its own growth, micro environment, and metastasis. Not only damage caused by acute inflammation can be the cause of tumor growth, persistent infections which cause chronic inflammation can cause it too. Helicobacter pylori is confirmed the main cause of stomach cancer – second most frequent in the world. Suppression of inflammation lowers the risk of cancer growth, but that isn’t the solution. Inflammation is double edged sword. Under tumor control inflammation helps its growth; it’s still one of the ways immune system deals with tumors. Suppressing inflammation in person that has weak immune system would only open up new frontiers for other infections. Continued research might find a way to use inflammation reaction against tumors and turn the cytokine and chemokine balance locally because suppressing inflammation globally isn’t the answer.

Item Type: Thesis (Bachelor's thesis)
Supervisor: Oršolić, Nada
Date: 2013
Number of Pages: 10
Subjects: NATURAL SCIENCES > Biology
Divisions: Faculty of Science > Department of Biology
Depositing User: Silvana Šehić
Date Deposited: 15 Oct 2014 10:59
Last Modified: 15 Oct 2014 10:59
URI: http://digre.pmf.unizg.hr/id/eprint/3067

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